REPOSITIONING OF ANTIARRHYTHMICS FOR PROSTATE CANCER TREATMENT: A NOVEL STRATEGY TO REPROGRAM CANCER-ASSOCIATED FIBROBLASTS TOWARDS A TUMOR-SUPPRESSIVE PHENOTYPE

Abstract Background Cancer-associated fibroblasts (CAFs) play a significant role in fueling prostate cancer (PCa) progression by interacting with tumor cells.A previous gene expression analysis revealed that CAFs up-regulate genes coding for voltage-gated cation channels, as compared to normal prostate fibroblasts (NPFs).In this study, we explored

The research aimed to provide the solutions for the method of selecting product development ultrastar dc hc570 strategies based on competitive advantage criteria including Quality, Cost, Delivery, Service, and Morale (QCDSM).The research was done in Micro, Small, and Medium Enterprises (MSMEs) of Ikat woven fabric in which the collecting data used

In Indonesia, transportation sector, specifically road transport consumed most energy compared to other sectors.Eventually, the energy consumption will increase due to the growth of vehicle number that also escalate emission.Vehicle emissions had been recognized as a significant contributor to atmospheric greenhouse gas (GHG) pollution.Heavy-duty v

ABSTRACT Understanding the relationship between body, health, and movement beyond biological determinism and the current biomedical paradigm should sepia plex consider other emerging interpretations that consider the multiplicity of the innumerable dimensions of which the triad can be composed as well as the different relationships that could exist

The succinate receptor (also known as GPR91) is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors.It is expressed in a variety of tissues, including blood cells, adipose tissue, the liver, retina and kidney.In these tissues, this receptor and its ligand succinate have recently emerged as novel mediators in lo